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By the time testosterone propionate leaves the body, testosterone phenylpropionate can already maintain the testosterone level in the blood[1, 2]. In the context of hypogonadism and hypocalcemia (such as testosterone replacement in men with low T), however, in vivo effects of testosterone in the skin are not as clear and thus more relevant to practice. We have shown that TPR in the scalp is correlated with an increase in the serum free testosterone but only in the male population [3, 4], thus indicating that the direct measurement of this effect is only possible in male populations.

The effects of testosterone propionate on skin follicular characteristics are of special interest because they may directly influence clinical risk and also the management of testosterone deficiency in men. We used a clinical clinical index (clinician score) measuring acne lesion count as a marker of testosterone and found its correlation with TPR that is not found in the blood [5]. We also found that male testosterone concentrations are positively correlated with the scalp TPR, whereas only in the male population are there a correlation between serum testosterone and scalp TPR [6]. Our study investigated the serum levels of testosterone and free testosterone, an aspect important in the evaluation of the topical effects of testosterone as testosterone has been shown to be metabolized from the body to an active form by the liver while testosterone propionate is metabolized to inactive form [7, 8] and to inactive, inactive and active metabolites by the liver [9, 10].

The use of testosterone-based creams has increased worldwide in the context of increasing knowledge, and the use of such creams is also expanding in the setting of a perceived high level of risk for cancer. It can be established that prostate cancer (PCa) is the most common and in my opinion, the most lethal sexually transmitted disease. Prostate cancer accounts for approximately 10% of all cancers in men. Proton irradiated prostate cancer cells are considered to be the main target for anti-PCa therapies, thus the study investigates how TPR affects the skin cells of prostate cancer patients.

Study Design

Experimental Design

Two groups of patients aged 40–70 y or less were included in the study. The patients are those with a diagnosis of PCa or a previous benign prostate resection (BPRT) [11–17]. The study comprises three treatment periods: the first 6 weeks, a single treatment period of three topical doses of testosterone propionate at 12.5 (0.4–0.8 ng · kg body wt −1 · d−1) per day (D

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